Contrast Essay Romeo and Juliet Example For Students

Differentiation Essay: Romeo and Juliet As a rule people say that William Shakespeare was and still is a legend. They are right. It is astonishing how Shakespeare’s play Romeo and Juliet composed hundreds of years prior can be better than Franco Zefferelli’s film creation of Romeo and Juliet, which had much better innovation to work with just decades back. In spite of the fact that the film showed up better, it forgot about some significant parts. The play would be advised to mind-set and plot subtleties which made it significantly more sensational and by a wide margin a superior introduction. One significant contrast between the play and the film happens in mind-set. A case of this is the marriage scene. In the marriage scene of the play, Romeo and Juliet act intense. The peruser can tell this by the manner in which the two talk. Romeo says that the Holy Words the Friar expresses can make something without an equivalent (Act II, Scene 6, Line 4) which is an extremely astute comment. While, in the film they kiss and chuckle the whole time. This leads the watcher to accept that Franco Zefferelli needed the two to look like numb-skulls, that they couldn't do anything the manner in which it is regularly done in light of the fact that they are kids looking for fast love. This is awful in light of the fact that it isn't exceptionally practical. In eal-life, youthful grown-ups would pay attention to the issue since they realize it is a significant advance throughout everyday life. Since the play isn't altogether attempting to make the two look terrible, it is the better creation. Another significant contrast in the state of mind of the play and the film is in the memorial service scene. The memorial service scene of the play is an intense occasion. Juliet’s family is disturbed and imagine that they are the reason for her â€Å"death†. Additionally, the Friar mitigates the group of the loss of youthful Juliet’s life (Act IV, Scene 5, Line 65). In any case, in the film form of the memorial service scene, again everybody is tragic yet his time the Friar lets out a snicker as he professes to appeal to God for Juliet. This is a significant distinction in such a case that somebody had seen the Friar laugh, it might have changed the whole play. They may have addressed him why he snickered yet since he would not have an explanation he may simply spill what he knows. Since the film was by and by ridiculous, the play is the better creation in this scene too. Some other significant contrasts between the play and the film happened in the plot subtleties. One case of this is in the start of the story. In the play, Romeo is simply getting over Rosaline â€Å"rejecting† him (Act I, Scene 1, Line 155). This implies he could have quite recently been disturbed. Bringing about him simply snatching the principal thing he could see which simply occurred as Juliet. On the off chance that he had never at any point met Rosaline he most likely would have never met Juliet either. In spite of the fact that in the film rendition of this part, all that the watcher knows is that Romeo is very vexed from something that was never raised. In the event that Franco Zefferelli had added this to his creation it would most likely bode well that him simply forgetting about it and having the watcher think about what was wrong with Romeo. Because of this distinction, the play by and by is better on the grounds that the parcel is more idea out then the film where the watcher needs to figure. Another distinction between the play and the film in plot subtleties is at the completion of the whole story. In the play, the families are at long last settled as Romeo and Juliet’s genuine memorial services occur. .u81025a1e4cc0e06a629dcc1c62dead77 , .u81025a1e4cc0e06a629dcc1c62dead77 .postImageUrl , .u81025a1e4cc0e06a629dcc1c62dead77 .focused content territory { min-stature: 80px; position: relative; } .u81025a1e4cc0e06a629dcc1c62dead77 , .u81025a1e4cc0e06a629dcc1c62dead77:hover , .u81025a1e4cc0e06a629dcc1c62dead77:visited , .u81025a1e4cc0e06a629dcc1c62dead77:active { border:0!important; } .u81025a1e4cc0e06a629dcc1c62dead77 .clearfix:after { content: ; show: table; clear: both; } .u81025a1e4cc0e06a629dcc1c62dead77 { show: square; change: foundation shading 250ms; webkit-progress: foundation shading 250ms; width: 100%; obscurity: 1; change: haziness 250ms; webkit-progress: murkiness 250ms; foundation shading: #95A5A6; } .u81025a1e4cc0e06a629dcc1c62dead77:active , .u81025a1e4cc0e06a629dcc1c62dead77:hover { darkness: 1; change: mistiness 250ms; webkit-change: murkiness 250ms; foundation shading: #2C3E50; } .u81025a1e4cc0e06a629dcc1c62dead77 .focused content zone { width: 100%; position: relative ; } .u81025a1e4cc0e06a629dcc1c62dead77 .ctaText { outskirt base: 0 strong #fff; shading: #2980B9; text dimension: 16px; textual style weight: intense; edge: 0; cushioning: 0; text-design: underline; } .u81025a1e4cc0e06a629dcc1c62dead77 .postTitle { shading: #FFFFFF; text dimension: 16px; textual style weight: 600; edge: 0; cushioning: 0; width: 100%; } .u81025a1e4cc0e06a629dcc1c62dead77 .ctaButton { foundation shading: #7F8C8D!important; shading: #2980B9; fringe: none; outskirt span: 3px; box-shadow: none; text dimension: 14px; text style weight: striking; line-tallness: 26px; moz-fringe range: 3px; text-adjust: focus; text-enrichment: none; text-shadow: none; width: 80px; min-stature: 80px; foundation: url(https://artscolumbia.org/wp-content/modules/intelly-related-posts/resources/pictures/straightforward arrow.png)no-rehash; position: total; right: 0; top: 0; } .u81025a1e4cc0e06a629dcc1c62dead77:hover .ctaButton { foundation shading: #34495E!important; } .u81025a1e4cc0e06a629dcc1c 62dead77 .focused content { show: table; stature: 80px; cushioning left: 18px; top: 0; } .u81025a1e4cc0e06a629dcc1c62dead77-content { show: table-cell; edge: 0; cushioning: 0; cushioning right: 108px; position: relative; vertical-adjust: center; width: 100%; } .u81025a1e4cc0e06a629dcc1c62dead77:after { content: ; show: square; clear: both; } READ: How does Priestley make a dramatization out of the topic of social obligation EssayThe Montague’s even choose to raise a gold sculpture of Juliet and the Capulet’s shake hand’s with them which are generally excellent signs that the long and unpleasant quarrel of the two families is finished (Act V, Scene 3, Line 295). Then again, the film just shows that he two families have met up. However, this is for an explanation that practically and two gatherings would met up for? a memorial service of one for one of their relatives. All that the families do to recognize each other is as they stroll into the congregation, they g o to confront their equivalent in the contrary family. This is most likely the greatest contrast out of the creations since one of the goal’s that Romeo, Juliet and Friar Laurence had was that this marriage would end the fights. The play’s rendition of this was better since no one truly needs to see a miserable story which Romeo and Juliet is until the end yet the play makes it an appy story (as it were) by one of Romeo and Juliet’s essential objectives being finished, despite the fact that they needed to pass on for it. Because of the entirety of the models recorded here, the temperament in the marriage scene, the mind-set in the burial service scene, and the plot subtleties before all else and the finish of the play, the play is point of fact, the better creation. Be that as it may, if Franco Zefferelli had made his film more as a masterpiece rather than a creation, and invested somewhat more energy in doing as such, he could have had himself probably the best film ever, which William Shakespeare did with his play.

Global International Business Technology and Positivity

Question: Examine about the Global International Business for Technology and Positivity. Answer: Presentation Australia has ended up being the initiator of new world wine maker by picking up the benefit from the progression of the innovation and inspiration of the regular conditions. The nation nearly gives wines effortlessly everywhere throughout the world. Wine industry is the one of the essential business of Australia deals of wine in this nation contributes extra 5.5 billion dollar to the Australian GDP since 2009 (Lereboullet et al., 2013). There are critical ideal potential and utilization is noted among the wine business in Australia, which was enlarged remarkably during the time of 2009. Maybe, as wine industry has extraordinary significance in Australia, so the nation has numerous open doors for the organizations drawing nearer and starting their business in wine industry. The forceful environmental factors, compromises of the market must be examined for settling on choices and discovering openings. This report comprises of the attraction and competency in the wine creation in Australia by utilizing Porters National Diamond Model. This is done due t breaking down the extent of beginning another business in this industry, which likewise gives a thought of entering the market in a legitimate manner. Watchmen National Diamond Analysis Figure 1: Porters National Diamond Analysis (Source: Spawton, 2013 pp-100) Vital and competition setting of the firm At present there are 2320 wineries arranged in Australia around 2009, among which a large portion of them are viewed as an individual organizations. There are significant four organizations which covers practically 70% of the Australian wine advertise. This is characterized as thee Oligopoly showcase. While taking cost preferences the greater part of the wineries situated themselves as the supplier of items which have center low worth. This is a direct result of the way that the late appearance commercial center situating is the key procedure (Spawton, 2013). Setup and approach are two significant viewpoints, which impacts a most significant job in assessing the ramifications of the disturbed circumstance (Edwards Spawton, 2013). It is critical to put more concentrate on the procedures and the structure of the organization as it will check the propriety of changes and assess on the off chance that it can make the organization a champ in the worldwide serious market. As per the Porters National Diamond Model, the investigation of the contention expresses that, it is putting more spotlight on the situating of the inward piece of the country (Angove et al., 2016). This adapting additionally impacts the restriction in the Australian market. There are a few vineyards in Australia; among them the most well known one is arranged in South Australia named as Barossa Valley. This is principally renowned for giving great grapes. What's more, another famous vineyard is Penfolds. These two vineyards are known for the top quality wine providers of South Australia. The organization can increase an expanded favorable position and furthermore can overcome the advancing troubles by gathering all the data about the wineries before these goes into a creative commercial center (Galbreath et al., 2014). Precious stone conditions The association can without much of a stretch set the functional objective market by investigating the requesting factors. Despite the fact that Australia has gigantic yield through the wine business, the need of the clients ensures that everybody adores wine and this will results into the appeal of wine in the commercial center. As per the Porters Theory, the requesting and harping clients impacts the association in a constant way to improve their merchandise and ventures. This viewpoint may help the association for keeping up their situation in the serious market. Figure 2: Production of Wine (Source: Galbreath, 2014, pp-300 ) At the current situation, wines are traded considerably more than the household deals inside the nation. The interest is expanding so that the adequate furthest reaches of the exportation isn't fulfilling up the needs. The local market of Australia has taken the general deals of the nation according to the requests of the occupants (Fleming et al., 2015). Furthermore, Australia positioned most elevated in estimating the per consumer consumption, which is only close to UK. Figure 3: Alcohol Consumption (Source: Sadras, 2014, pp-44) It is discovered that, the per consumer consumption of Australia is extra than the normal of OECDAverage wine use nations. The residential market is urgent available to be purchased of wine. The local needs of the Australian market mark the nation in distinct manners. In examination with the French wine the nearby purchasers increase low division of item dependability. 37% of the wine consumers enquire for guidance in the shop or café and 64% about those picked their wine as per their sort, as opposed to their brands (Mozell Thach, 2014). Also, there are not many of wine decisions accessible which comes up to rival the Australian wines. As per the shows of the neighborhood wine commercial center, the position and zone are not the matter of core interest. Figure 4: Expenditure of Australian Wine (Source: Galbreath, 2014,pp-90) The above chart is demonstrating that the use of the Australian wine has expanded up till the year 2008. In 2009 the creation brought down definitely by 30%, where as the salary from the familial deals dense by a little edge, which showed an expansion in normal devoured cost inside Australia (Caron et al., 2014). This inclination has affected the wineries to make new compelling brand technique for delivering the high greatness wines. Possibilities Australian wine business has created up quick and beneficially 2000 years prior. The nation has begun it from some little grape firms. In correlation with France and Italy, Australia possessed a speedy and successful history. It shows the situation of Australia in the worldwide wine advertise (Wilson et al., 2015). The claim to fame of Australian wine is: essentially all the nation has all kind of climate and soil assortment. This guarantees all kind of wine creation from red wine to harbor wines. In this manner it is one advantage to the clients to look for the clients considerations by furnishing high caliber of wines with its distinctive assortment. In light of the Michael Porters Model, the odds and jobs gave by the administration are estimated as the remote properties of the copy of Diamond. The upstanding impact in the different nuts and bolts of the jewel is the fundamental explanation for it (Szolnoki, 2013). If there should be an occurrence of administrative positions, on the off chance that the transparency of the previous Australian exchange is diminished, at that point it will at the same time hamper the requests and it would likewise put an impact to different factors of different determinants. By considering the case identified with possibilities, this exploration is concentrating on two explicit factors clarified by the fiction survey. The main quality in the rundown is considered with the movement procedure that the ongoing scene wine nations are experiencing. Another purpose behind this is commitment of defeat in the creative domains (Overton Murray, 2013). It was discovered that, the nations getting forceful in the Australian business was beginning with the creation and improvement of wine grapes. The previously mentioned event had an excellent helpful outcome on the improvement in wine business, however this reality doesn't clarify that these nations were controlled by the old wine delivering nations. Presently it is getting critical to build up the prosperous wine industry to as the farming ventures are happy to be a piece of the wine business (Grant et al., 2015). Moreover it is getting imperative to ad lib the modern approaches to that will influence the disguised part for the expanded intensity. Likewise, plainly, the offer of wine is expanding as the new World wine states are expanding their requests. The climbing progression of the necessity of these made merchandise is expanding quickly by every year. Related and supporting businesses All sort of industry that underpins the handling and creation of wine, for example, showcasing, transportation, and viticulture are known as the related and following enterprises. Grapes are the most significant crude component for building up the wine business (Santini et al., 2013). The greater part of the wine creating organizations are appended with the crude material providers of various territories. The purpose for keeping a dregs number of crude material provider isto maintains a strategic distance from the expansion of cost of grapes. The creation of wine grapes over past 6 years shows the quick decrease underway of grapes since 2008 (Morrison Rabellotti, 2013). In 2010 theproduction was consolidated by 8.9%. If there should be an occurrence of the creation of the crude assets and products a colossal drop was indentified. This assessed the forecast of ascent of wine cost because of oversupply. Variables (Input) The elements required as the conditions can be called attention to partitioning it into two angles: one is profoundly particular assets and other is home developed assets for other people. As per the determination of the Michael Porter the nearby home developed assets can be accomplished by improving the innovation as its estimation is diminished. This is extraordinary that the home created are pivotal for the business where different ventures are utilizing the typical items. This is absolutely applicable to the business referenced here (Felzensztein, 2014). The successive sort of grapes are the essential crude material for the wine delivering system and in particular hardly any assortments make a major change in the predominance of wine. The atmosphere of Australia is ideal for the manor of the grapes. The necessary highlights of the atmosphere for the manor of grapes are: less contamination, consistent condition of the atmosphere, prolific soil and a lot of daylight and so forth (Bryant Garnham, 2013). One viewpoint that must be featured is Australians have select stroke for creating and delivering

Comparing the Moral Superiority of Grendel and Frankenstein :: Comparison Compare Contrast Essays

Looking at the Moral Superiority of Grendel and Frankenstein Looking for companions, they discovered foes; looking for trust, they discovered despise. Social outsiders just need to live as all of us live. Regularly, in our preference of their sort, we oust them from our tip top society. Notwithstanding our own point of view, society judges who is adequate and who isn't. Probably the best individuals of the sum total of what time have been socially inadmissible. Van Gogh discovered solace just in his specialty, and with a lady who reliably denied his enthusiasm. Edgar Allen Poe was considered unique - without a doubt. These extraordinary men, just as Grendel and Frankenstein, don't â€Å"fit† into society. Additionally like these men, Grendel and Frankenstein are interestingly better than the remainder of humankind. Their prevalence is seen through their cunning over live in a general public that alienates their sort, their actual valor instead of society's sentimental view, and the numbness on which society's assessment of them is frame d. Grendel, however he needs to execute to do as such, works very well in his own circle. Grendel makes due in an unfriendly atmosphere where he is despised and dreaded by all. He lives in a cavern secured by firesnakes in order to genuinely, just as profoundly, separate himself from the general public that disdains, yet respects, him. Grendel is the beast existent by which [humankind] figures out how to characterize itself(Gardner 73). Hrothgar's thanes persistently attempt to smother Grendel's fiendish anger, while he essentially wishes to live in agreement with them. Like Grendel, Frankenstein additionally figures out how to live in a general public that detests his sort. Frankenstein likewise should slaughter, however this is just because of the individuals' hatred of him. Amusingly, the very specialist who bore him presently look through the globe looking for Frankenstein's demolition. Indeed, even the ever-cherishing fatherly figure presently gets some distance from this pariah from society. Frankenstein excursions to the furthest reaches of the world to escape from the cultural ills that cause society to despise him. He dares to the harshest, generally ruined, most dreadful spot known to man, the north shaft. He lives in segregation, neglected acknowledgment of the cold icy masses. All things considered, Dr. Frankenstein follows, pushing his creation to the edge of the world, trusting he would tumble off, never to be seen or gotten notification from again. Frankenstein escapes from his dad until the Doctor's demise, where Frankenstein joins h is dad in the ceaseless, quiet acknowledgment of death.

A Fair View of Essay Samples Images

A Fair View of Essay Samples Images The Little-Known Secrets to Essay Samples Images Whenever your analytical essay is all typed up, they will be able to help you make sure it's as excellent as it can get. The most effective persuasive short essays often concentrate on controversial problems. Which is the reason why we here offer you some persuasive essay samples that could assist you with your own. Don't forget that any argumentative essay sample you'll discover on the internet will require a full rewriting in order to prevent plagiarism. The introductory paragraph is perhaps the most significant paragraph in the essay since it is the very first and possibly last opportunity to produce an effect on the reader. The kind of such a story is known as the photo essay. No matter the subject, the structure is exactly the same for any persuasive essay. The objective of your introduction is to have the reader interested in your analysis. What you will need is is a blueprinta foolproof approach to receive your essay structured. The way the topic affected you'll play a huge part in the way you will write your essay. Most academic essay topics usually ask you to select a side in an argument or maybe to defend a specific side against criticism. Selecting an excellent topic for your essay is among the most crucial and frequently tricky parts for many students. Life After Essay Samples Images The mental impacts of the mass media's portrayal of the ideal body is able to cause individuals to resort to unhealthy techniques of losing weight to attain that athletic look that all these desire. Though there are lots of negative effects media places on women, in addition, there are many positive outcomes. The media needs to create healthful behaviors and lifestyles in order to permit women to truly feel good about themselves. Social networking portrays how a person who has an ideal body' should look. Effective writing is n't just crucial in schools, but in addition in business. In case you have some questions, get expert assistance from WritemyEssayOnline.com. Effectively written reports demonstrate that an individual is competent and intelligent. 1 way to work out when you're summarizing instead of analyzing is to look over your support. Top Essay Samples Images Choices Early childhood influences, including parents and caregivers, have a big influence on the self-image. The subject of how media negatively impacts the image of young girls will give a reason to why the media should quit limiting the idea about what counts as being beautiful. On the other hand it's challenging to not watch reality shows to find out what drama rich folks have and the way they solve problems. Examine the Eiffel Tower, and what number of photographs are taken of it. Observe how the picture utilizes color or absence of color. First, the styling of the female models in most of the images could imply they are soldiers not prostitutes, either with the usage of accessories or by keeping up the military inspired colour palette. Take note of the way the picture is cropped. You should begin your writing process by selecting a concept in which you're interested and truly feel comfortable writing about. The principal component which creates a persuasive essay in English stand out from the remainder of assignments is the use of reasoning. The simplest approach to learn the form of an essay is to realize the writer's point of view. If you wish to figure out how to compose a fantastic persuasive essay, you're looking in the proper spot! One of the most intriguing truth about Picture Essay is that it's written with just no plot or objective in mind. When you have gathered ideas on the subject, you should properly place your thoughts into words. Negative stereotypes are everywhere and involve almost everyone regardless of what profession or company you're in. In order to spot the most effective possible tactics to prevent plagiarism, an individual must know the significance of plagiarism. If you think that you are unable to learn a foreign language, you aren't very likely to achieve that. Ladies watch celebrities and have a tendency to follow along with their habits since they wish to be like them. They will then be able to stop feeling pressured by the media. They are faced with challenges when they are championing for social change.

Essay on Tsar After 1905 - 1195 Words

Tsar After 1905 It would be true to say that the Tsar remained unscathed after 1905, as he remained on the throne until 1917. However, it would also be true to say that the Tsar was permanently damaged by the 1905 revolution. Before 1905, there was much unrest and discontent. Famines in 1897, 1898 and 1901, made the already struggling countryside even worse, and the usually loyal peasantry held uprisings in two provinces in 1902. The Russo-Japanese war caused further unrest following a series of defeats, including that of Port Arthur. This caused revolutionary outbreaks to spread rapidly throughout Russia and gave way for various Liberal groups to press for their demands for a†¦show more content†¦Nicolas II was forced to make concessions. He would never fully recover from this event as Revolutionaries saw this as an example where violence achieved aims. On 3rd March1905, the Tsar offered a consultative assembly to try and bring an end to the violence. The rest of 1905 continued in a similar way. Defeats in Japan caused further outrage in Russia, which caused the Tsar to make further concessions. For example; the Battle of Tsushima on the 27th May, (where the Russian Baltic fleet were destroyed), lead to a disorder of widespread strikes in June and August, which lead to the Tsar promising an Imperial Duma on the 19th August. The formation of the Union of Unions on the 8th March was significant, as the middle classes and peasants formed new opposition to the Tsar. This affected the Tsar long-term as never before had these groups opposed him. Nicholas II was forced to introduce new measures to regain the support of these people. Further defeats at Mukden and Tsushima meant that the Tsar was in danger of loosing more support. His repeated pledges of March were ridiculed as no plans were put into action and further protests continued. During the summer, the Tsars position worsened as his own troops turned against him. Several ships went on strike due to poor conditions and in June,Show MoreRelatedHow Far Was the Russo – Japanese War of 1904 – 1905 Responsible for the Outbreak of the 1905 Revolution?1021 Words   |  5 PagesThe Russo – Japanese war did is seen as a short term factor that was responsible for the 1905 revolution, however there are many other short term and long term factors which also contribute to being responsible for the 1905 revolution. The way the Tsar ran the country, social problems, changing society inside and outside Russia, Bloody Sunday etc... The Russo – Japanese war saw Russia lose to Japan. Russia saw itself as a great and powerful country, compared to others, Russia wanted to expandRead MoreWhy Did the 1905 Revolution Fail746 Words   |  3 PagesWhy did the 1905 revolution fail? One of the main reasons that the 1905 revolution failed was because the October Manifesto merely only satisfied the middle classes’ appetite for reform. 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Psychopathic Serial Killers Essay - 1668 Words

â€Å"Gunning for you and all mankind, I’ve lost my mind. Psychotic, rabid dementia, I won’t be fine.† – Avenged Sevenfold While the members of Avenged Sevenfold, a Heavy Metal band, are not psychotic killers, their lyrics refer to the destruction of other humans. Many people have a morbid curiosity about a psychopathic murderer’s mind. The criminal justice system has a number of trained specialists to study the minds of psychotic killers. Psychopathic killers usually grow up in similar, unstable homes. However, they usually have completely different crime scenes. Most of these killers have different motives for murdering their victims. Psychopaths are stereotyped. They are shown as vicious, violent people, but in reality they†¦show more content†¦Antisocial disorder is a helpful diagnosis when then question is whether a person is likely to have a bad behavior; it does not discriminate against criminals. Only one out of every five antisocia l people are psychopaths. Psychopaths brains process differently. Researchers say that there is a disability that impairs the emotional development. Signs of psychopathy may be seen as young as the age of five years old (LaBrode 151-160). Behaviors of psychopaths consist of lying, prone to boredom, sexual promiscuity, no long term goals, irresponsibility, early childhood behaviors, juvenile delinquency, shallow, and manipulation. They are indifferent about pain and do not fear it (Jadczyk). They usually get worse, not better after standard treatments like group therapy. Seeing others’ vulnerabilities gives them opportunities to hone their manipulation skills (LaBrode 151-160). Theodore Robert Ted Bundy is a good example of a psychopath who appears to be normal. He was born November 24, 1946 in Burlington, Vermont. He grew up in Tacoma, Washington with his mother and his step-father. Ted hated his step-father and because his mother picked his step-father over Ted, he grew to hate her as well. 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RBC Analysis free essay sample

Executive Summary In today’s demanding market, it is essential to know how to make good investments. The following is an in depth qualitative and quantitative analysis of the Royal Bank of Canada. First, RBC and its subsidiaries will be introduced including information about its history and current situation. The qualitative analysis will consist of RBC’s general information, history, business segments, and corporate social responsibility. Secondly, ratios and other quantitative information pertaining to RBC’s investment situation will be analyzed. Finally, with respect to the qualitative and quantitative data, an investment recommendation will be made Investment Criteria A company’s ethics and proper management are just as important for their success as their financial data. In order to decide whether or not to invest in a company one must research the company inside and out starting with where the company has come from all the way to their current situation. A company’s history is of the utmost importance because it reveals management trends and past ethical decision making that could reoccur. Another important aspect of a company’s history is their international expansion and the companies they have done past business with. The industries companies choose to merge with are a good indicator of where they will invest their money in the future. More specific to the banking industry, sustainability has become one of the most important criteria for investment. Especially after the financial collapse of 2008, banks with strong sustainability stood out and gained ground on the high-risk high reward banks. From a quantitative perspective, data trends can help predict if a company is on a small skid or headed toward future collapse. Ratios can help determine how quickly a company can pay back their liabilities as well as how efficient they are being with their shareholder’s money. A company’s stock may rise or fall depending on their current situation and how the market is fairing overall. The amount of assets and acquisitions a company makes can lead a potential investor to believe they are expanding. Usually good financial data investment criteria are a current ratio 2:1 and an ROA 5%. Company Introduction The Royal Bank of Canada is Canada’s largest bank by assets and market capitalization. The bank has offices in Canada, United States and 49 other countries. Currently, there are 80,000 full and part time employees at RBC with close to 15 million clients worldwide. The company has a good balance between retail and wholesale banking with over two-thirds of their revenue coming from Canada. The other main geographical markets include U. S. (16%), while all other revenue is distributed internationally (17%). (See Appendix A) Qualitative Analysis History The history of a company, industry it is present in, and prior success are some of the main factors when considering investing in a company. RBC has been a leading Canadian bank since June 22, 1864 when it was incorporated as the Merchants Bank of Halifax. Its name was changed to The Royal Bank of Canada in 1901. Twenty-four year later it merged with the Union Bank of Canada on the basis of 1 share of Royal Bank stock for two shares of Union Bank stock. Since then, RBC has taken advantage of many international joint ventures and foreign acquisitions. Most notably in Cuba, Britain, and West Germany. Post-1980, the bank created joint ventures in China with China International Trust Investment Corp. and began acquiring financial companies in North America. All of the sudden, RBC found themselves competing with large new international banks. During this time, the bank also made a larger commitment to their corporate social responsibility as their charitable donations reached 25. 5 million in 1999. Most recently, RBC has been striving to become a more broad-based financial services group rather than a traditional commercial bank. Although RBC wanted to keep with it’s main goal of being the #1 banker in Canada, they also wanted to build a stronger overall North American identity. Technology based products took the lead in the bank’s new American market strategy. In going along with this strategy, RBC acquired the world’s first Internet bank in order to take advantage of e-banking services. Finally, the bank has developed a new global brand strategy in response to their growing North American presence, which requires the RBC financial group banner to each business platform and operating subsidiary. Business Segments The Royal Bank of Canada has five main business segments. The largest of these segments is their personal and commercial banking segment, which makes up 56% of their earnings. RBC was named the largest and most profitable retail banking in Canada as well as the 2nd largest bank by assets in English Caribbean (†Corporate Profile†). The bank provides cross-border banking for Canadian clients and U. S. wealth management clients. Their second largest business segment is their capital markets sector. Their capital markets department deals with corporate and investment banking, equity and debt distribution as well as trading. This segment is recognized as the 10th largest global investment bank by net revenue and was also named the best investment bank in Canada across equity, debt, and MA five years in a row (â€Å"Corporate Profile†). The third business segment of RBC, which makes up 11% of their earnings, is their wealth management division. Investment, trust, credit, and other wealth management and asset management solutions are all included in wealth management. The division was named top six global wealth mangers by assets as well as ranked #1 in Canada in both retail and asset management (â€Å"Corporate Profile†). Finally, their insurance and investor treasury services make up the last 11% of the bank’s total earnings. The insurance segment deals with life, health, home, auto, travel, and wealth accumulation solutions. Achievements of the insurance segment include receiving high marks for â€Å"Likelihood to Recommend† and â€Å"Ease of Doing Business† (â€Å"Corporate Profile†). Their investor treasury services provide global custody, fund administration, and asset servicing to institutional investors. (See Appendix B) SWOT Analysis Strengths: Leading Market Position: RBC is Canada’s largest bank measured by assets and market capitalization. Leading market position in Canada enables the bank to gain economic economies of scale. Significant Presence in the US and UK RBC is the sixth largest full-service brokerage firm in the US and operates in a network of 42 states. In the UK, RBC is considered a Gilt-edged market maker and actively trades in either conventional or index-linked gilts (â€Å"Welcome to ALADIN†). Strong Balance Sheet RBC has a strong capital ratio and common ratio that are much greater than those required under Canadian standards. Also, the bank’s operating leverage declined between the years 2008 and 2010 showing potential from raising new capital (â€Å"Welcome to ALADIN†). Weaknesses: Asset Quality Deterioration RBC’s asset quality has been deteriorating since 2007. More specifically their gross impaired loans to total loans and acceptances ratio has grown between the years 2008 to 2010. Growth and profitability concerns at US operations Although RBC realized an overall growth in revenue in 2009, they also experienced a loss of net income. The US is RBC’s second largest market and can deeply impact the companies overall growth as a whole. Opportunities: International Expansion RBC has a rich history of international acquisitions over the past 30 years. Continuing with this aggressive strategy paves the way potential increases in revenue and profit expansion. Canada’s Promising Economic Prospects Canadian GDP has shown positive growth within the past two years. Attributing to this growth has been an increasing demand for commodities and improving global financial market conditions. Threats: Increasing Interest Rates As Canadian interest rates rise, so does the potential for a decrease in demand for financial services. High Taxation Banks in Canada are taxed at a much higher rate than other countries. In addition to Canada’s high taxation, the bank also faces high tax rates in the US; it’s second largest market (â€Å"Welcome to ALADIN†). Corporate Social Responsibility RBC has a clearly defined community and sustainability mission as they have been contributing to building a better future since 1864. Emphasis is put mainly on investing in the future by delivering quality products, protecting the environment, and sustaining a productive workplace. In respect to the community, RBC invests millions of dollars in health, sports, and the arts. More specifically they created RBC Play Hockey, which provides hockey gear to under privileged children. RBC believes that the game of hockey can bring a community together and provide a fun, competitive atmosphere among kids. Twenty grants, each of which was $25,000, will be awarded across North America (â€Å"Corporate Profile†). In respect to the environment, climate change, biodiversity, and water are weighed heavily upon. The RBC Blue Water Project helps educate people about the importance of preserving clean water in order to have enough fresh water for the future. The main component of the program is a ten-year, $50 million donations program, which supports not-for-profit organizations that protect watersheds and ensure access to clean drinking water (â€Å"Corporate Profile†). In RBC’s workplace is built upon the notion of shared values, and a sense of responsibility toward others. They look to provide a safe and flexible working environment with career growth opportunities. Also, the bank provides short and long term savings and wealth accumulation programs for their employees. Quantitative Analysis (See Appendix C) Balance Sheet: RBC has realized a 14% increase in assets over the last three years. This growth in assets is an indicator for an increase in stock returns. However, many times a growth in assets leads to sluggish returns as too many assets weigh down the bank (â€Å"Welcome to ALADIN†). Basic accounting procedures require all financial information on the balance sheet to even out. Therefore since RBC’s assets grew by 14%, so did they liabilities and shareholders equity. This increase in the bank’s liabilities can be attributed to inventory being purchased, issuing bonds payable at a discount, retirement costs for current employees etc. Paid-in capital, the year’s net profits, or a new share offering can increase shareholder’s equity. Shareholder’s equity is especially important for banks such as RBC because of the amount of capital they are given to invest. Cash Flow: Net investments cash flow represents the gain or loss in cash flow from investments made in the financial market and operating subsidiaries. In 2009, RBC had a positive cash flow indicating they were not investing heavily at the time. However, in the next two years, huge investments were made which made their net investments cash flow to go far below zero. Having a negative overall cash flow is not necessarily a bad thing, but instead may be a result of heavy investments. Nevertheless, RBC has maintained sustainability and kept their overall cash flow positive despite their large investments. Income Statement/Retained Earnings: RBC’s total revenue has decreased by 5% over the last three years. However looking deeper will reveal a huge increase in the company’s revenue over the past five years. In 2007 and 2008 the total revenue was $22,462 and $21,582 respectively (â€Å"Welcome to ALADIN†). This data revels an overall increase in revenue of 22% between 2007 and 2011, which any company would be proud of. In addition, RBC shows their continued effort toward sustainability as their retained earnings increased by almost 20% in the past three years (â€Å"Welcome to ALADIN†). In effect, this increase shows that a healthy profit exists even after dividends are given out to the shareholders.

13 Quotes to Share with Your Dad This Fathers Day

13 Quotes to Share with Your Dad This Fathers Day Good fathers are difficult to find. If you have a gem of a father and you wish to make him feel special, here is your chance. Wish him a very happy fathers day with some brilliant fathers day quotes. If you have shied away from expressing your warm feelings to your father, dont lose this opportunity. These charming fathers day quotes can awaken and rebuild long-lost relationships. Erika Cosby   You know... fathers just have a way of putting everything together. Clarence Budington Kelland He didnt tell me how to live; he lived, and let me watch him do it. Gabriel Garcia Marquez   A man knows when he is growing old because he begins to look like his father. Lord Chesterfield As fathers commonly go, it is seldom a misfortune to be fatherless; and considering the general run of sons, as seldom a misfortune to be childless. National Urban League Slogan   Dont make a baby if you cant be a father. Aldous Huxley   Sons have always a rebellious wish to be disillusioned by that which charmed their fathers. Helen Rowland   A mans desire for a son is usually nothing but the wish to duplicate himself in order that such a remarkable pattern may not be lost to the world. Austin OMalley   The worst misfortune that can happen to an ordinary man is to have an extraordinary father. Confucius   The father who does not teach his son his duties is equally guilty with the son who neglects them. William Penn   He who is taught to live upon little owes more to his fathers wisdom than he who has a great deal left him does to his fathers care. Charles Wadworth   By the time a man realizes that maybe his father was right, he usually has a son who thinks hes wrong. Anonymous   Small boys become big men through the influence of big men who care about small boys. Tom Wolfe, The Bonfire of the Vanities   Sherman made the terrible discovery that men make about their fathers sooner or later... that the man before him was not an aging father but a boy, a boy much like himself, a boy who grew up and had a child of his own and, as best he could, out of a sense of duty and, perhaps love, adopted a role called Being a Father so that his child would have something mythical and infinitely important: a Protector, who would keep a lid on all the chaotic and catastrophic possibilities of life.

12 Angery Man Essays - Fiction, Literature, Theatre, Free Essays

12 Angery Man Essays - Fiction, Literature, Theatre, Free Essays 12 Angery Man Twelve Angry Men Sometimes in life your professions reflect on your personalities. Twelve Angry Men is an example of where this occurs. Twelve men are brought together in a room to decide whether a boy is guilty of killing his father. Whether they brought good or bad qualities from their profession, they all affected the outcome. The leadership skills of Courtney Vance, the compassion of Dorian Harwood, and the opinionated Tony Danza affected the actions and decisions in the jury room. Courtney Vance is a high school football coach; his position in the jury room is a foreman. On the football field, Vance acts as a mediator, a leader, and an organizer. As a foreman for this trial, Vance definitely carries all those traits into the jury room with him. If it were not for Vance, there would not have been any order in the jury room. He acts as a coach in the jury room as he formed fine lines of respect. He acts as a mediator for all of the arguments that went on in the jury room. Every time, Vance is there to calm everyone down and gain back order in the room. His leadership skills also shine in the jury room as well. He controls and leads every discussion, speaking order, voting, and demonstration. Vance takes on the leading role and handles it well. He also brings organization into the jury room by organizing the juries, the discussions, and the votes. With the excellent traits that Vance brings into the jury room, he allows the trial to run smoothly and effectively. Dorian Harwoods profession as nurse also shapes his actions in the jury room. In the jury room, he acts with compassion and respect. As a nurse he does the same. His compassion lies in caring for another. He relates that to the trial by thinking of the boy as one of his patients. He wants him to have a fair chance at life, and therefore wants him to have a fair trial. In the jury room, he acts with respect because he is very unsure about the case, and really does not know how he feels about things. So when it is his turn to talk he passes to hear the others before he makes the wrong assumption. With these actions he shows a lot of respect for not only the boy on trial, but also to the other juries. Harwood definitely shows compassion and respect in the jury room, and all of these strong traits come from his experience as a nurse. Tony Danza, a salesman, definitely brings his working traits with him in the jury room. As a salesman, he is impatient, opinionated, and rude. Tony does not care about anyone but himself. He shows that he is very impatient by not even thinking about the trial but rather the baseball tickets that he has for that night. He just wants to get out of there as soon as he can. He is very opinionated and that definitely stands out in the jury room. He does not care what anyone has to say. He has his own beliefs and does not care or want to hear anyone elses views. He is also known to be rude, because he shows no compassion or thought towards the boy on trial and he just wants to get it over with. He does not even stop to think that someones life is on the line, he is too concerned about his own. Tonys profession does not give him the best qualities, as he does not have the best qualities in the jury room. Courtney Vance, Dorian Harwood, and Tony Danza are three men who are shaped by the professions in which they live. Their professions give the men certain qualities, good and bad, that they carry with them into other parts of their lives. Each man shows these qualities in the jury room and they affect the actions and decisions that are made.

What managing leading, coaching, and motivating styles do managers Essay

What managing leading, coaching, and motivating styles do managers adopt in organisation A - Essay Example Money that is, in many instance, the life savings of clients are entrusted to the care of the banks. Banks are governed by rules to reinforce confidence that their clients’ money is protected. Banks are mandated by the government to follow these rules and transgressions are dealt with stiff penalties, including forfeiture to conduct business in extreme cases. The rules are most of the time the source of conflict between customers and the bank. These frictions, if allowed to escalate, lead to the diminished trust and confidence of the clients for the bank and when it continues to be unresolved, it will result to the withdrawal of the clients’ business from the bank. It is thus the responsibility of the bank’s customer frontlines or customer representatives to maintain, manage, and care for the bank’s clients that will strengthen and restore its trust and confidence for the bank. A customer that has the full faith and confidence for its bank is a satisfied customer who is willing to increase the volume of business and transactions for the benefit of the bank. An increase in transaction and business translates to an increase in its profitability and viability. Management in context of this paper is the provisioning of the necessary resources and giving decisions so that employees can do their job properly. The objective is to be able to convert business requirements into tangible results (Tannenbaum & Schmidt, 1958). Management style is the manner in which resources are provided and decisions are delivered to the employees to implement. This would include Managers who: makes decision and announces it; sells decision or convinces subordinate that it is the right decision; presents ideas and invite question; present tentative decision; presents problems, solicit suggestion then make decision; defines limits and ask group to make decision; permits subordinates to function within limits (Tannenbaum & Schmidt, 1958). Leadership

The Tourism Industry of Dubai Essay Example | Topics and Well Written Essays - 2500 words

The Tourism Industry of Dubai - Essay Example Dubai is known internationally as one of the premier tourist destinations of the world, especially among the high-income and elite group of tourists. It is also regarded as one of the richest places in the world where Dubai is always desired for mass tourism. There is apparently an endless variety of vacation opportunities in this part of the world with positive intervention and support from both government and industries. Notably, the government of UAE aims at developing Dubai as the chief tourist destinations in the world, making use of its unique tourism features operating as a differentiated tourist hub and thus obtaining the competitive advantages of almost no close substitutes. The place is considered as the jewel of UAE because of the fact that it offers luxury, sumptuousness and outstanding facilities to the tourists with a magnificent blend of tradition and modern cultures. It has been observed that outstanding hotels, shopping malls, and skyscrapers are the well-known chara cteristics of Dubai. It has been further viewed that Dubai offers great opportunities and verities for all potential tourists in accordance with the taste of the people visiting the city. It has also been noted that the shopping malls of Emirates situated in this place provide a variety of options to the customers from fashion to home furnishing. Furthermore, Dubai also focuses on developing its sports tourism industry sector facilitating various sports through Ski Dubai resort and other similar amenities (Henderson, 2006).... Gigantism engaging huge amounts of money had been the vision of tourism in Dubai owing to which many prominent projects of tourism development have raised significant threat to the scarcity of natural resources. Apart from environmental threats, the city is also affected by regular governmental intervention from the national and international levels, which is often termed as the ‘War Zone’. It is worth mentioning in this context that US military forces had been operating in Dubai, using the city as a vital base to perform spying activities on Iran, which has significantly influenced tourism rates within the city. Money laundering has also been a mostly debated issue in Dubai. Moreover, Dubai is also criticised for the slavery related issues. Behind the ultra modern and luxurious hotels of the city, there lies a dark world where slavery is still being practiced. Issues related to forced labour are also seemed to be quite significant in the city. Irrespective of such issue s, Dubai had been able to maintain its peace avoiding any considerable terrorist attacks and rendering due scope to attract a variety of tourists from around the world (Davis, 2007; Keane & McGeehan, 2008). Emphasising these characteristics of the tourism market in Dubai, the paper would intend to evaluate the extent to which the city deciphers or rather illustrates the features of modern urban tourism. The intention of the paper will be thus concentrated on connoting if Dubai presents a new paradigm of urban tourism. Discussion Illustration of Dubai as a Tourist Place Dubai is known internationally as one of the premier tourist destinations of the world, especially among the

HIV (Human Immunodeficiency Virus) Essay Example for Free

HIV (Human Immunodeficiency Virus) Essay HIV (Human Immunodeficiency Virus) causes AIDS (Acquired Immune Deficiency Syndrome) that disables the immune system.  It was discovered in 1983 .HIV enters the body through the bloodstream and duplicates itself rapidly.  The victim is susceptible to infectious diseases that eventually are fatal (1). Statistically, HIV/AIDS is the number one killer of African-American women ages 25 to 34, according to the Centers for Disease Control and Prevention.  Between 2000 and 2003, they were nineteen times more likely than White females and five times more likely than Hispanic females to contract the disease.   African-American men were seven times more likely than White men and three times the rate of Hispanic men to contract HIV/AIDS (2). In 2008, there is still not a cure for AIDS.  Instead, scientists have discovered drugs that can slow down the progression of the disease. Protease inhibitors (PIs) are antiviral drugs that slow down the spread of HIV (1). The virus produces a protein called protease so that it can replicate itself.  Ã¢â‚¬Å"Protease cuts long chains of proteins and enzymes into shorter chains, the first step in the process by which HIV infects a cell† (1).  If this doesn’t happen, replication does not continue. In 1987, AZT was the first anti-HIV medication that was created.   It showed hope and kept people healthier longer.   However, the side effects were very high for men.   Since that time, more HIV medications have evolved.   Antiretroviral therapy usually consists of combinations of nucleoside/nucleotide reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or fusion inhibitors, which are prescribed in the later stages of HIV (19). Dual protease inhibitor therapy is also being used clinically (3).  They are also associated with improving morbidity and mortality of HIV-positive persons (5).  Although these drugs are expensive, they have proven to be the most successful therapy in managing HIV.   However, some patients don’t comply 100% with their treatments.   This is largely due to the side effects. Sometimes they make a patient feel worse than the actual disease. The most commonly reported ones are abdominal pain, abnormal bowel movements, diarrhea, fatigue, headache, and nausea.   Children usually develop a skin rash. The more serious side effects are liver problems and pancreatitis.   Some patients have also seen large increase in triglyceride ad cholesterol levels.   Diabetics saw an increase in their blood sugar levels.   Other patients developed diabetes while taking protease inhibitors (16). Presently, nine PIs have been approved for use in the United States and Europe:   amprenavir, atazanavir, fosamprenavir, lopinavir, indinavir, ritonavir, saquinavir, tipranavir, and nelfinavir. Three non-nucleoside reverse transcriptase inhibitors (NNRTIs) are used for treatment of HIV:  nevirapine, delavirdine, and efavirenz (7). Drug treatment selection depends on factors such as drug resistance, tolerability, drug interactions, and effectiveness. Therapeutic drug monitoring (TDM) â€Å"has been proposed so that practitioners may better maintain appropriate plasma concentrations of drugs in their patients by identifying interactions with other medications and assessing medication adherence   (7). Figure 1 shows the structures of these compounds. Fig. 1. Chemical structures of protease inhibitors and non-nucleoside reverse transcriptase inhibitors. About 50% of â€Å"treatment-naà ¯ve patients† don’t have continued antiviral response after one year of therapy (18). In some cases, there is a development of drug resistance and metabolic complications.   Also, â€Å"there is increasing evidence that virological treatment failure is correlated with variations in the pharmacokinetic parameters of drugs (20).   This can be due to drug interactions, low bioavailability, and variations in metabolic enzyme activity.   Atazanavir (ATV) has good oral bioavailability and a favorable pharmacokinetics profile (18).   With this in mind, patients can mostly take a once-daily dose. A separate analytical method has been recently published for quantifying ATV in human plasma using solid phase extraction and HPLC with PDA (photodiode array) detection at 201 nm (18).   This method provides excellent separation of ATV from its internal standard, clozapine (CLZ) and the other PIs, thus, obtaining an accurate measurement of the drug (see figure 2). CLZ elutes at 8.9 minutes, and ATV elutes a 24.4 minutes. A 40-ml injection resulted in a recovery yield of 100%. Fig. 2.   Chromatogram of ATV with PIs/NNRTIs (8000 ng/ml) spiked with CLZ Nelfinavir mesylate has been shown in phase III controlled clinical trials to significantly reduce viral load and increase CD4+ cell counts when used with reverse transcriptase inhibitors. It’s prescribed as part of triple drug combination therapy (9). CD4+ are helper T cells.   They are important for immune reconstitution in patients that are receiving antiretroviral therapy (10).   After a large number of these cells are destroyed, AIDS develops (7). Six clinical trials was conducted in the past ten years using 2, 148 HIV-infected children enrolled in the Pediatric AIDS Clinical Trials Group treatment trials (10).   Patient ages varied from 2 to 7 years of age.   The focus was to observe short-term variability of CD4 percentages.   The study found that 49% of patients had CD4 percentages above 25%.   32% of patients had CD4 counts between 15% and 24%; 19% were less than 15%.   Finally, 5.4% had a CD4% of less than 5% (10). In June 2006, Darunavir (DRV) was licensed in the United States.   It is a promising PI that is active against HIV strains that are resistant to the other PIs that currently on the market (17).   It is prescribed in 600-mg doses that are taken twice daily with 100 mg of ritonavir that acts as a booster. Protease inhibitors are associated with unfavorable pharmacokinetics and many side effects such as gastrointestinal disturbances and lipid abnormalities (5).  Four of the most common PIs used are indinavir, ritonavir, saquinavir, and nelfinavir (3).  Ã¢â‚¬Å"Monitoring blood concentration of PIs, which can indicate both therapeutic and toxic levels of the drugs as well as patient noncompliance with the medication, may improve the care of both HIV-infected adults and children† (3). When ritonavir was first introduced, it was given in doses of 600 mg every 12 hours. â€Å"However, patient intolerance of full doses led to its primary use as a pharmacologic enhancer to increase the concentrations in plasma of a second protease inhibitor to improve the convenience of antiretroviral regimens by extending the dosing interval, reducing pill burden, and /or eliminating food-induced reductions in pharmacokinetic exposure† (8).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Researchers used High Performance Liquid Chromatography (HPLC) to determine concentrations of PIs in blood.  Various methods have been used to study the pharmacokinetics and drug interactions. Interpreting plasma levels can be used to â€Å"individualize drug dosage of antiretrovirals (4). Quality control (QC) procedures must be done to ensure that these methods are accurate and precise.  Ã¢â‚¬Å"Such procedures usually include intralaboratory (internal) method validation, intralaboratory QC procedures, and participation in an interlaboratory QC program for antiretroviral drugs† (4). Since the latter hadn’t been done before, it was established so that laboratories can obtain better measurement results of antiretroviral drugs. Nine laboratories participated in the first part of the program.  The first part of the experiment involved the measurement of the protease inhibitors:  indinavir, nelfinavir, ritonavir, and saquinavir.  All had a specified purity of 99% or higher.  QC samples were prepared by spiking blank plasma from HIV-negative volunteers with PI standard. The low concentrated standards ranged from 0.087 to 0.15 mg/L while the intermediate concentrated standards contained ranged from 2 to 3 mg/L of all four PIs.  Finally, the high-concentrated standards contained approximately 5 to 11 mg/L of drug.  All drugs were dissolved in methanol following accurate weighings and diluted with blank plasma (4). High Performance Liquid Chromatography (HPLC) was used to analyze twelve samples.  All laboratories measuring more than one protease inhibitor used as assay for â€Å"simultaneous determination† (4).  Six laboratories used HPLC/UV and three labs used HPLC-MS/MS. Mass spectrometry detection is often recommended for measurement of low concentration levels.  Also, this type of analysis is usually faster and â€Å"does not require complete resolution of drugs for detection and quantification† (5).  Only five laboratories were able to measure all four PIs.  Three laboratories were not able to determine nelfinavir.  One laboratory only measured indinavir (4). Acceptable accuracy results are between 80% and 120%.  Only indinavir resulted in an acceptable accuracy of 80%.  The remaining PIs had between 36% and 74% accuracy.  These results should encourage laboratories to improve their analytical methods and QC procedures.  Other PIs, such as amprenavir and lopinavir, can be analyzed as well (4). HIV-positive plasma samples are heat inactivated before analysis, approximately 58 °C for 40 minutes, to decrease the risk of infection to the operator.  They may also go through a freeze/thaw cycle. As with the QC study, blank plasma was spiked with seven PIs (indinavir, amprenavir, atazanavir, ritonavir, saquinavir, lopinavir, and nelfnavir) at low, intermediate, and high concentrations measured in ng/ml.  Certain assays only require 100  µl of plasma for analysis.  Ã¢â‚¬Å"This is advantageous when measuring PI concentrations as part of clinical studies as they often necessitate hourly sampling to generate complete PK profiles; therefore less blood can be drawn from the patient† (5).  In addition, seven PIs can be quantified in one assay, but impossible to assay all seven in a single preparation. â€Å"The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS) has emerged as the developmental method of choice supporting clinical and pre-clinical pharmacokinetic studies† (13). Recovery for the HPLC-MS/MS methods was above 87% for all seven drugs at all three concentration levels (5).  It was successful in quantifying seven PI concentrations in plasma of HIV positive persons that participated in a run time of nine minutes.  Therefore, the assay may be used for determining PI concentrations in semen, lymphocytes, and cerebrospinal fluid (5). A fast and highly-sensitive LC-MS-MS method was developed that could analyze five protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir) in one run using an internal standard.   Sample sizes were small (ng/ml) and run times were approximately 5 minutes.   Recoveries for all five PIs were between 87% and 92%(11). Tipranavir is part of a class of non-peptidic PIs that works against both â€Å"wild-type virus and variants resistant to current PIs†(6).  It also has a high genetic barrier.  Tipranavir is prescribed in a 500-mg dose taken in combination with 200 mg of ritonavir twice daily as part of antiretroviral therapy for patients with HIV-1 strains that are resistant to multiple PIs (6). Fig. 3. Tipranavir chemical structure   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  An HPLC-UV method has been validated and is currently applied when monitoring tipranavir (TPV) plasma levels in HIV patients.  Samples were prepared for solid phase extraction (SPE) by conditioning the cartridges with 0.1% phosphoric acid, pH 7.  TPV stock solutions with a concentration of 5 mg/ml were diluted from with 50% methanol. Samples were spiked with TPV at 1.875, 7.5, 18.75, 37.5, 60, and 75  µg/ml in triplicate. QC samples were diluted with blank plasma and phosphate buffer to 5.625, 22.5, and 67.5  µg/ml.  Clozapine was used as the internal standard (6).  5-ml aliquots of blood samples were obtained from HIV infected patients.  The plasma obtained from centrifugation was heated at 60 ° C for one hour in a water bath. TPV in plasma was measured at a UV absorbance of 201 nm with a retention time of 32.2 minutes. Its internal standard, clozapine (CLZ) has a retention time of 8.3 minutes (6). Figure 4 below shows the chromatogram of TPV, its internal standard, and all other PIs and NNRTIs  present.   Figure 5 shows TPV and its internal standard CLZ only. Fig. 4. Chromatogram of plasma control sample of TVP (22.5 mg/ml) spiked with internal standard and all PIs and NNRTIs. Fig. 5. Chromatogram of calibration sample of TVP (37.5 mg/ml) spiked with internal standard CLZ. Isocratic HPLC methods combined with the use of UV and fluorescence detection produces more sensitivity. Amprenavir is a fluorescent compound.   Its internal standard PR25 can also be seen under fluorescence (see figure 6). Fig. 6.   Blank plasma with 100 ng/ml amprenavir and 1000 ng/ml of PR25 seen under fluorescence. In conclusion, much progress has been made in the development of protease inhibitors and other antiretroviral therapy. HPLC with UV detection has been the most commonly used method of analysis.   It is rapid, simple, and highly sensitive.   LC-MS-MS has been noted at the developmental method of choice for clinical and pre-clinical pharmacokinetic studies (13).   More compounds can be analyzed in less time.   Also, they can be used for methods using other human biological matrices. For the majority of protease inhibitors, all side effects are not known. In 2007, darunavir was the new HIV protease inhibitor with eleven other antiretroviral agents on the market.   They can affect patients that have diabetes, liver problems, and hemophilia; their conditions can worsen as a result of taking PIs. Only a patient’s health care provider can determine the best treatment option REFERENCES Nagel, Rob. 2007. Protease Inhibitors. UXL Encyclopedia of Science; [cited 2008 May 8], Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docnum=cv2644301082. Health Hotline:   HIV and Genital Herpes [cited 2008 May8]; Available from http://www.ebony.com. â€Å"HPLC Assay for Common Protease Inhibitors Developed.†Antiviral Weekly; [cited 2008 May 07; Available from http://galenet.galegroup.com/servlet/SciRC?ste=1docNum=A60069570. Aarnoutse, Rob E., Verweij-van Wissen, Corrien P.W.G.M., van Ewijk-Beneken Kolmer, Eleonora, W.J., Wuis, Eveline, W., Koopmans, Peter P., Hekster, Yechiel A., and Burger, David, M. 2001. International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma; Antimicrobial Agents and Chemo 46(3): 884-886. Dickinson, Laura, Robinson, Lesley, Tjia, John, Khoo, and Saye, Back, David. 2005. Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry; J of Chrom. B 829:82-90. Colombo, S., Beguin, A., Marzolini, C., Telenti, A., Biollaz, J., and Decosterd, L.A. 2006.   Determination of the novel non-peptidic HIV-protease inhibitor tipranavir by HPLC-UV after solid-phase extraction; J of Chrom. B 832:138-143. Rezk, Naser L., Tidwell, Richard R., and Kashuba, Angela D.M. 2004.   High-performance liquid chromatography assay for the quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma; J of Chrom. B 805:241-247. Shelton, Mark J.,Hewitt, Ross G., Adams, John, Dela-Coletta, Andrew, Cox, Steven, and Morse, Gene D. 2003. Pharmacokinetics of Ritonavir and Delavirdine in Human Immunodeficiency Virus-Infected Patients; Antimicrobial Agents and Chemo 47(5): 1694-1699. Zhang, Kanyin E., Wu, Ellen, Patick, Amy K., Kerr, Bradley, Zorbas, Mark, Lankford, Angela, Kobayashi, Takuo, Maeda, Yuki, Shetty, Bhasker, and Webber, Stephanie. 2001.Circulating Metabolites of the Human Immunodeficiency Virus protease Inhibitor Nelfinavir in Humans:   Structural Identification, Levels in Plasma, and Antiviral Activities; Antimicrobial Agents and Chemo 45(4): 1086-1093. Carey, Vincent J., Pahwa, Savita, and Weinberg, Adriana. 2005.   Reliability of CD4 Quantitation in Human Immunodeficiency Virus-Positive Children:   Implications for Definition of Immunologic Response to Highly Active Antiretroviral Therapy; Clinical and Diagnostic Lab Immunology 12(5): 640-643. Chi, Jingduan, Jayewardene, Anura L., Stone, Judith A., Motoya, Toshiro, and Aweeka, Francesca. 2002.   Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS; J of Pharm and Biomedical Analysis 30:675-684. Verbesselt, R., Van Wijngaerden, E., and de Hoon, J. 2007. Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: Amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite; J of Chrom. B 845:51-60. Frerichs, Valerie A., DiFrancesco, Robin, and Morse, Gene D. 2003. Determination of protease inhibitors using liquid chromatography-tandem mass spectrometry; J of Chrom, B 787:393-403. Gangl, Eric, Utkin, Ilya, Gerber, Nicholas, and Vouros, Paul. 2002. Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry; J. of Chrom. A 974:91-101. Turner, Michele L., Reed-Walker, Kedria, King, Jennifer R., and Acosta, Edward P. 2003. Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography; J. of Chrom. B 784:331-341. 2008. Kaletra. [Cited 2008 May 16], Available from http://www.heartandsoul.com. D’Avolio, Antonio, Siccardi, Marco, Sciandra, Mauro, Lorena, Baietto, Bonora, Stefano, Trentini, Laura, and Di Perri, Giovanni.2007. HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients; J. of Chrom. B 859:234-240. Colombo, S., Guignard, N., Marzolini, C., Telenti, A., Biollaz, J., and Decosterd, L.A. 2004. Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction; J. of Chrom. B 810:25-34. Weller, Dennis R., Brundage, Richard C., Balfour, Jr., Henry H., and Vezina, Heather E. An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma; J. of Chrom. B 848:369-373. Sarasa-Nacenta, Maria, Lopez-Pua, Yolanda, Mallolas, Josep, Blanco, Jose’ Luis, Gatell, Jose’ M., and Carne’, Xavier. Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high- performance liquid chromatography; J, of Chrom. B 757:325-332.

Compare and Contrast The Day After Tomorrow and Outbreak Essay

Which of these movies provides a more effective wake-up call about impending global catastrophes? â€Å"The Day After Tomorrow† and â€Å"Outbreak† both raise important concerns regarding the world that we live in. The first movie seems to serve mainly as a warning that as a people of this planet we need to do everything in our power to stop destroying our world. â€Å"Outbreak† demonstrates the vulnerability of the United States and for that matter all nations of the world in dealing with large epidemics. Though both movies raise legitimate concerns they also both are quite sensationalized in order spice it up for moviegoers. The most effective movie in providing a wake up call for humanity is totally debatable and is entirely dependent on the eye of the beholder. In â€Å"The Day After Tomorrow† a climatologist’s warning of the possibility of massive cataclysmic climate changes caused by global warming go unheeded. His predictions of the consequences of such actions just so happen to occur sooner than anyone had ever expected. This movie served as the ultimate example what could happen if as a world community we do not clean up our acts. Continued consumption of nonrenewable resources, increased carbon dioxide emissions and further depletion of the Ozone layer could though most likely not on the scale illustrated occur in one form or another. The moral of this film is summed up by Dennis Quaid’s character in the last scene when he mutters his last few lines stating that hopefully humani...

Swot Dropbox

Strengths: first one to have the idea of cloud storage with synchronization, accessible where you want from any devices, simple design easy to use, exactly same data everywhere you go principle of synchronization, saved in dropbox. com if your laptop is out of use you have access to your files online, enable multi-users to share files, revision-history button to recover deleted files, 2GB storage for free to attract the consumers, pop up if you connect a usb stick or SD card to your computer â€Å"do you want to synchronize these files with Dropbox, turn loyal customer into salesperson: 250MB for free if referral (1/4 of Dropbox users come this way), no files capacity transfert limitation.Weaknesses: need access to internet to download Dropbox, 2GB limited storage for free (competition eg amazon offers 5GB for free as already mentioned by Janine), you cannot store more than the available place on your device, dealing with paid search advertisement, security problem in 2011.Opportuni ties: engagement on social media, deal with HTC to be default cloud storage on Androids, talking about it with 6 other phone firms then PC and TV, E marketing benefits: control, reach, interactivity.Threats: competitors such as Google or Apple could overtake the leader position in B2C market, competition offers lower prices, if Dropbox does not implement himself better in the enterprise market they could loose market shares of B2C market because it has been proven that home market copies enterprise market, possibility of cloud back up system being attacked by external or internal users ? introduction of a spyware through Dropbox

Plus ça Change - French Expression

Expression: Plus à §a change, plus cest la mà ªme chose Pronunciation: [plu sa sha(n)zh plu say la mem shoz] Meaning: the more things change, the more they stay the same. Literal translation: more it changes, more its the same thing. Register: normal How to Use Plus à §a Change The pessimistic French expression plus à §a change, plus cest la mà ªme chose is very often cut down to just the first clause: plus à §a change... / the more things change... The shortened French expression is often used in English too, particularly British English.In either language, plus à §a change indicates a certain disillusionment or resignation regarding whatever is being talked about. A company makes all kinds of policy changes, for example, but the personnel issues are unaffected. A couple go to marriage counseling, but continue fighting about everything. A new sheriff comes to town, but there is no noticeable impact on crime. New people, new promises, but the same old problems - plus à §a change.... Variations: Plus à §a change, plus cest pareil: The more it changes, the more its the same.Plus à §a change (et) moins à §a change: The more it changes (and) the less it changes